Radical-Substitution Reactions

Radical-substitution reactions occur with the replacement of one substituent by another, but have free radical species as intermediates.

In this section, the most significant named organic reactions are listed, classified according to the type of chemical reaction. Among the named organic reactions of the radical substitution type we can highlight the following:

Glaser coupling

Glaser coupling

References:
C. Glaser, Chem. Ber. 2, 422 (1869)
C. Glaser, Ann. Chem. Pharm. 154, 159 (1870)

Gomberg-Bachmann-Hey reaction

Gomberg-Bachmann-Hey reaction

References:
M. Gomberg, W.E. Bachmann, J. Am. Chem. Soc. 46, 2339 (1924)
D.H. Hey, W.A. Waters, Chem. Rev. 21, 1, 169 (1937)
J. Elks, J.W. Haworth, and D.H. Hey, J. Chem. Soc. 1940, 1284

Heck reaction

Heck reaction

References:
R.F. Heck, J.P. Nolley, Jr., J. Org. Chem. 37, 2320 (1972)

Hunsdiecker reaction (Hunsdiecker-Borodin Reaction)

Hunsdiecker Reaction (Hunsdiecker-Borodin Reaction)

References:
C. Hunsdiecker, H. Hunsdiecker, E. Vogt, U.S. patent 2176181 (1939)
H. Hunsdiecker, C. Hunsdiecker, Chem. Ber. 75, 291 (1942)
A. Borodin, Justus Liebigs Ann. Chem. 119, 121 (1861)

Kolbe electrolysis synthesis

Kolbe electrolysis synthesis

References:
H. Kolbe, Justus Liebigs Ann. Chem. 69, 257 (1849)
A. Crum Brown, J. Walker, Justus Liebigs Ann. Chem. 261, 107 (1891)
A. Crum Brown, J. Walker, Justus Liebigs Ann. Chem. 261, 107 (1891)
H. Hofer, M. Moest, Justus Liebigs Ann. Chem. 323, 284 (1902)

Meerwein arylation

Meerwein arylation

References:
H. Meerwein, E. Buchner and K. van Emster, J. Prakt. Chem. 152, 237 (1939)
H. Meerwein et al., Ger. Patent 714, 573 (1935 to Schering AG)

Pschorr reaction

Pschorr reaction

References:
R. Pschorr, Chem. Ber. 29, 496 (1896)

Reed reaction

Reed reaction

References:
C.F. Reed, U.S. Patent 2046090 (1933)
C.F. Reed, U.S. Patent 2174110 (1934)
C.F. Reed, U.S. Patent 2174492 (1938)

Simonini reaction

Simonini reaction

References:
A. Simonini, Monatsh. Chem. 13, 320 (1892)
A. Simonini, Monatsh. Chem. 14, 81 (1893)

Suarez reaction

Suarez reaction

References:
J.I. Concepion et al, Tetrahedron Lett. 25, 1953 (1984)
J.I. Concepion et al, J. Org. Chem. 51, 402 (1986)

Wohl-Ziegler reaction

Wohl-Ziegler reaction

References:
A. Wohl, Chem. Ber. 52, 51 (1919)
K. Ziegler et al., Ann. Chem. Pharm. 551, 80 (1942)

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